Work

Antisense RNA of Proto-Oncogene c-fos Blocks Renewed Growth of Quiescent 3T3 Cells

Year: 1987

Type: article

Abstract: Mouse 3T3 cells were transformed with an antisense c-fos gene fused to a mouse mammary tumor virus promoter. In transformants that integrated a large number of antisense c-fos sequences, the usual large increase in c-fos mRNA and protein following stimulation of quiescent cells by platelet-derived growth factor was blocked in the presence of dexamethasone. These cells subsequently also failed to show the stimulation of DNA synthesis normally induced by platelet-derived growth factor. Appropriate expression of c-fos appears to be a prerequisite for reentry of quiescent cells into the cell cycle.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.7.2.639-649.1987

Authors: K Nishikura, J M Murray

Institutions: The Wistar Institute, University of Pennsylvania

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Science Foundation, American Cancer Society, American Heart Association

Awards: Three-dimensional Structure of the Eukaryotic Flagellum, Regulatory Mechanism of Cellular Oncogene Expression