Work

Cytotoxic Activity of Methanolic Extracts of Solanum Erianthum D. Don

Year: 2014

Type: article

Abstract: Objective: The study was aimed to evaluate cytotoxic activity of the methanolic extracts of Solanum erianthum on HeLa, HepG-2 and MCF-7 cell lines. Methods: The percentage viability of the cell lines were carried out using trypan blue dye exclusion method and the cytotoxicity of the extracts was evaluated by MTT assay . Result: Solanum erianthum leaf and fruit extract showed significant cytotoxic activity on the tested cell lines with IC 50 values ranging from 111.67 to 385 µg mL -1 . Fruit extract showed potent cytotoxic activity on MCF-7 (IC 50 111.67 µgmL -1 ), followed by leaf extract (IC 50 150.50 µgmL -1 )on HeLa cell line using MTT assay. Cell viability assay showed that fruit extract was very active on MCF-7 and leaf extract was effective against HeLa. Conclusion: The experiment performed reveals that Solanum erianthum can be used in development of anticancer drug.

Source: International Journal of Pharmacy and Pharmaceutical Sciences

Authors: Radhika Mahadev, H. Ramakrishnaiah, V. Krishna, A. P. Deepalakshmi, N. Naveen Kumar

Institution: Kuvempu University

Language: English

Topic: Phytochemical Studies and Bioactivities

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1872793013

FWCI: 0.407

Cites: 30

Cited by: 15

Related to: 10