Work

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.

Year: 1986

Type: article

Abstract: Nuclear microinjection of c-H-ras DNA induced DNA synthesis in reversibly nonproliferating quiescent human cells. The proto-oncogene and oncogene forms were equally effective inducers. In contrast, c-H-ras DNA either alone or in combination with the adenovirus E1A gene did not cause terminally nondividing senescent cells to synthesize DNA.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.6.8.2990

Authors: C K Lumpkin, J E Knepper, J S Butel, J R Smith, O M Pereira-Smith

Institutions: United States Department of Veterans Affairs, Baylor College of Medicine, Veterans Health Administration

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health