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Nephroprotective potential of Graptophyllum pictum against renal injury induced by gentamicin.

Year: 2015

Type: article

Abstract: OBJECTIVES: To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. MATERIALS AND METHODS: Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum at 300, 150, 75 mg/kg, respectively. Nephroprotective activity was evaluated by measuring thiobarbituric acid-reactive substances (TBARS), biochemical markers Glutathione (GSH), Glutathione-S Transferase(GST), Superoxide dismutase (SOD), Catalase (CAT), serum urea and creatinine levels. RESULTS: Results obtained showed that gentamicin induced nephrotoxic rats exhibited lower activities of biochemical markers and raised levels of TBARS, serum creatinine and urea. Remarkably, after treatment with G. pictum extract, anomalous levels of biochemical markers, lipid peroxidation and serum creatinine were returned to normal. CONCLUSION: The results propose that G. pictum has nephroprotective effects, and can be a promising natural source against gentamicin induced nephrotoxicity.

Source: PubMed Central

Authors: Keloth Kaitheri Srinivasan, Jessy Elizabeth Mathew, Kerryn Joseph A D'Silva, Richard Lobo, Nimmy Kumar

Institutions: Shri Madhwa Vadiraja Institute of Technology and Management, Manipal Academy of Higher Education

Language: English

Topic: Chemotherapy-induced organ toxicity mitigation

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education

OpenAlex ID: W1880625092

FWCI: 1.171

Cites: 14

Cited by: 13

Related to: 10