Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling.
Year: 2010
Type: article
Abstract: BACKGROUND: Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. MATERIALS AND METHODS: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. RESULTS: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1. CONCLUSION: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway.
Source: PubMed
Institution: Uppsala University Hospital
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1881405668