Work

Genetics of pancreatic neuroendocrine tumors: implications for the clinic

Year: 2015

Type: article

Abstract: Pancreatic neuroendocrine tumors (PanNETs) are a common and deadly neoplasm of the pancreas. Although the importance of genetic alterations in PanNETs has been known for many years, recent comprehensive sequencing studies have greatly expanded our knowledge of neuroendocrine tumorigenesis in the pancreas. These studies have identified specific cellular processes that are altered in PanNETs, highlighted alterations with prognostic implications, and pointed to pathways for targeted therapies. In this review, we will discuss the genetic alterations that play a key role in PanNET tumorigenesis, with a specific focus on those alterations with the potential to change the way patients with these neoplasms are diagnosed and treated.

Source: Expert Review of Gastroenterology & Hepatology

DOI: 10.1586/17474124.2015.1092383

Authors: Antonio Pea, Ralph H Hruban, Laura D Wood

Institutions: University of Verona, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute