Work

Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

Year: 2015

Type: article

Abstract: A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c5ob01837d

Authors: E. M. Rigsbee, C. Zhou, C. M. Rasik, A. Z. Spitz, A. J. Nichols, M. K. Brown