Work

T cell therapies-are T memory stem cells the answer?

Year: 2015

Type: article

Abstract: T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.

Source: Europe PMC (PubMed Central)

DOI: 10.3978/j.issn.2305-5839.2015.08.13

Authors: Jacqueline K Flynn, Paul R Gorry

Institutions: Burnet Institute, The University of Melbourne, Monash University, RMIT University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1886852946

FWCI: 0.329

Cites: 31

Cited by: 8

Related to: 10