Work

Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus

Year: 1987

Type: article

Abstract: Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.

Source: Journal of Virology

DOI: 10.1128/jvi.61.8.2639-2641.1987

Authors: J W Gnann, J A Nelson, M B Oldstone

Institutions: Scripps Research Institute, Vaccine and Gene Therapy Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke