Work

The Same CCAAT Box-Binding Factor Binds to the Promoter of Two Coordinately Regulated Major Histocompatibility Complex Class II Genes

Year: 1991

Type: article

Abstract: Using competition mobility shift, methylation interference, and proteolytic clipping DNA binding assays, we demonstrate that the protein binding the major histocompatibility complex A beta CCAAT box is indistinguishable from the protein previously named NF-Y, which binds the major histocompatibility complex E alpha CCAAT box. Although the two CCAAT boxes share the same 10-base core sequence, termed the Y box, their flanking sequences, known to be important for binding, are very different.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.11.1.578

Authors: M J Kern, J G Woodward

Institutions: University of Kentucky, Albert B. Chandler Hospital

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: G490193105, CELLULAR &MOLECULAR CONTROL OF IA ANTIGEN EXPRESSION