Year: 2015
Type: article
Abstract: Progressive sequence alignment is one of the most commonly used method for multiple sequence alignment. Roughly speaking, the method first builds a guide tree, and then aligns the sequences progressively according to the topology of the tree. It is believed that guide trees are very important to progressive alignment; a better guide tree will give an alignment with higher accuracy. Recently, we have proposed an adaptive method for constructing guide trees. This paper studies the quality of the guide trees constructed by such method. Our study showed that our adaptive method can be used to improve the accuracy of many different progressive MSA tools. In fact, we give evidences showing that the guide trees constructed by the adaptive method are among the best.
Source: BMC Bioinformatics
Authors: Qing Zhan, Yongtao Ye, Tak-Wah Lam, Siu-Ming Yiu, Yadong Wang, Hing-Fung Ting
Institutions: Harbin Institute of Technology, University of Hong Kong
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,990
OpenAlex ID: W1888761835