Commentary: Necrobiotic Xanthogranuloma
Year: 2011
Type: editorial
Abstract: Chen and colleagues describe the interesting case of a 68-year-old man presenting with facial and neck edema and mediastinal mass, with eventual diagnosis of Necrobiotic Xanthogranuloma (NXG) and associated plasma cell dyscrasias and lymphoproliferative disorder1. The rarity of this condition precludes it from being studied on a large scale, but as cases are reported, with review of the literature as so beautifully done by Chen et al, we can hopefully gain a better understanding of the pathophysiology and treatment.
Necrobiotic Xanthogranuloma (NXG) was first described in 1980 by Kossad and Winkelmann in which they discussed 8 patients with xanthomatous plaques, noted to have monoclonal gammopathy, predominantly IgG kappa type2. Since then, more than 100 patients with this disorder have been described, with approximately 80% of them associated with a monoclonal gammopathy.
Source: Europe PMC (PubMed Central)
Author: Yvonne A. Efebera
Language: English
Topic: Skin Diseases and Diabetes
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W189276959