Clonal origins of lymphoproliferative disease induced by Epstein-Barr virus
Year: 1986
Type: article
Abstract: Analysis of immunoglobulin gene rearrangements in 16 B-cell lineages clonally propagated from two mononucleosis patients supported the notion that mononucleosis is a polyclonal B-lymphoproliferative disorder. Three of seven cell clones from a patient with a fatal B lymphoma revealed the same pattern of immunoglobulin gene rearrangement, indicating that this patient's disease was oligoclonal. The three similar clones were propagated from two sites (blood and spleen), indicating that they represent a metastatic cell lineage which arose during the patient's fatal B lymphoproliferation.
Source: Journal of Virology
Authors: N A Brown, C Liu, C R Garcia, Y F Wang, A Griffith, R S Sparkes, K L Calame
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G2231263484, G77511209
OpenAlex ID: W1892923052