Work

Dual Catalytic Decarboxylative Allylations of α‐Amino Acids and Their Divergent Mechanisms

Year: 2015

Type: article

Abstract: The room temperature radical decarboxylative allylation of N-protected α-amino acids and esters has been accomplished via a combination of palladium and photoredox catalysis to provide homoallylic amines. Mechanistic investigations revealed that the stability of the α-amino radical, which is formed by decarboxylation, dictates the predominant reaction pathway between competing mechanisms.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.201503644

Authors: Simon B. Lang, Kathryn M. O'Nele, Justin T. Douglas, Jon A. Tunge

Institution: University of Kansas

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Center for Research Resources

Awards: Avance II 500 High Performance Digital NMR Spectrometer System, AVIII HD 400 NMR spectrometer to replace existing DRX 400