Year: 2010
Type: article
Abstract: In this work we describe the identification of a copper-inducible regulon in Mycobacterium tuberculosis (Mtb). Among the regulated genes was Rv0190/MT0200, a paralogue of the copper metalloregulatory repressor CsoR. The five-locus regulon, which includes a gene that encodes the copper-protective metallothionein MymT, was highly induced in wild-type Mtb treated with copper, and highly expressed in an Rv0190/MT0200 mutant. Importantly, the Rv0190/MT0200 mutant was hyper-resistant to copper. The promoters of all five loci share a palindromic motif that was recognized by the gene product of Rv0190/MT0200. For this reason we named Rv0190/MT0200 RicR for regulated in copper repressor. Intriguingly, several of the RicR-regulated genes, including MymT, are unique to pathogenic Mycobacteria. The identification of a copper-responsive regulon specific to virulent mycobacterial species suggests copper homeostasis must be maintained during an infection. Alternatively, copper may provide a cue for the expression of genes unrelated to metal homeostasis, but nonetheless necessary for survival in a host.
Source: Molecular Microbiology
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Mtb Proteasome-Associated Factors and Virulence, G1658097173, TARGETING DEFENSES OF MYCOBACTERIUM TUBERCULOSIS, G3062614105, Pathogen Functional Genomics Resource Center , G4393179445, M.tb Survival Regulatory Genes, G4828030085, G501094345, Virulence Regulation by the Mycobacterium tuberculosis Proteasome, Infectious Disease and Basic Microbiological Mechanisms., NEW ANIMAL MODELS FOR TUBERCULOSIS (TB), G6524422613, G681440218, G74957556
OpenAlex ID: W1894302566