Work

Mammographic density as a mediator for breast cancer risk: analytic approaches

Year: 2012

Type: article

Abstract: Mammographic breast density has been found to be associated with breast cancer risk. Many of the traditional risk factors for breast cancer are themselves associated with mammographic breast density. A natural question that arises in this setting is the extent to which the effects of breast cancer risk factors are mediated by breast density and the extent to which such effects are through other pathways. We discuss analytic approaches to address these questions of mediation and also discuss how such approaches can accommodate potential interaction between risk factors and mammographic density and can accommodate case-control study designs.

Source: Breast Cancer Research

DOI: 10.1186/bcr3157

Authors: Tyler J VanderWeele, Hans-Olov Adami, Rulla M Tamimi

Institution: Harvard University

Language: English

Topic: Digital Radiography and Breast Imaging

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190