Work

Inside Cover: Recombinant Expression and Phenotypic Screening of a Bioactive Cyclotide Against α‐Synuclein‐Induced Cytotoxicity in Baker′s Yeast (Angew. Chem. Int. Ed. 29/2015)

Year: 2015

Type: article

Abstract: Cyclotides are naturally occurring microproteins with a circular Cys-knot topology found in plants. In their Communication on page 8390 ff., J. A. Camarero et al. show the heterologous expression of cyclotides inside live yeast cells. This approach was used to produce a cyclotide to inhibit α-syn-induced cytotoxity in a synucleopathy model.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201505052

Authors: Krishnappa Jagadish, Andrew Gould, Radhika Borra, Subhabrata Majumder, Zahid Mushtaq, Alexander Shekhtman, Julio A. Camarero

Institutions: University of Southern California, State University of New York, University at Albany, State University of New York

Language: English

Topic: Biochemical and Structural Characterization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1896327646

FWCI:

Cites:

Cited by:

Related to: 10