Year: 2013
Type: article
Abstract: Transdermal route has some advantages over other drug administration routes. These include avoidance of first pass effect (hepatic metabolism), better pharmacokinetic profile, reduction of side effects and good patient compliance. The greatest obstacle for the drugs to be delivered through the skin is overcoming the impermeable outermost layer of the skin – the stratum corneum. Quite a few enhancement techniques can be used to overcome the stratum corneum barrier and facilitate transdermal drug delivery. These include various passive (penetration enhancers, liposomes) and active approaches (electroporation, iontophoresis, microneedles), which are of prime interest for transdermal drug delivery research area.
Source: Slovenian Medical Journal
Authors: Zorec, Barbara, Préat, Véronique, Miklavcic, Damijan, Pavselj, Natasa
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1896380648