Work

Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours

Year: 2008

Type: article

Abstract: Testicular germ cell tumours (TGCTs) are prevalent cancers among young men. Currently, there is no reliable animal model for TGCTs. To establish such animal models, we have explored the possibility of intratubular testicular transplantation as means to deliver tumour cells into the seminiferous tubules of host animals. Our results demonstrated that transplanted cells could effectively populate the testis of a recipient mouse and develop into TGCTs. In addition, the donor cells could be transfected with a specific transgene before transplantation, thereby providing an approach to evaluate the specific effects of gene functions in the oncogenic processes. Hence, depending on selection of specific donor cells or mixtures of donor cells, transplantation models of TGCTs could be significant for studies on the pathogenesis, diagnosis and therapies of such a prevalent and important cancer in men.

Source: International Journal of Experimental Pathology

DOI: 10.1111/j.1365-2613.2008.00611.x

Authors: Yunmin Li, Tatsuo Kido, Jinping Luo, Michiko Fukuda, Ina Dobrinski, Yun‐Fai Chris Lau

Institutions: University of California, San Francisco, University of Pennsylvania, Sanford Burnham Prebys Medical Discovery Institute

Language: English

Topic: Testicular diseases and treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development