Year: 2010
Type: conference-paper
Study design: Observational Study
Abstract: ammatory related changes beyond the cytokines including the interaction between infl ammatory response system and neuroactive tryptophan metabolites that brought imbalance in neuroprotective kynurenic acid arm and neurodegenerative 3-hydroxykynurenine and quinolinic acid arm of the tryptophan catabolic pathway was proposed in neuro-degeneration hypothesis of depression. Method: A series of studies on human plasma and CSF changes and their associations to clinical symptoms and response to treatment and certain SNPs of genes from the related enzymes were carried out. Results: It was observed that the neuroprotective, kynurenic acid was signifi cantly lower and one of the neurodegenerative metabolites 3-hydroxykynurenine was higher in the plasma of drug naive depressed patients. Th e plasma kynurenic acid concentration and neuroprotective ratio (kynurenic acid/kynurenine) gave clear discrimination between the patients and controls with reasonable sensitivity and the specifi city. Th e CSF fi ndings showed similar direction. Th e fi nd
Author: Aye-Mu Myint
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1897071989