The right inhibition? Callosal correlates of hand performance in healthy children and adolescents callosal correlates of hand performance
Year: 2012
Type: article
Study design: Observational Study
Abstract: Numerous studies suggest that interhemispheric inhibition-relayed via the corpus callosum-plays an important role in unilateral hand motions. Interestingly, transcallosal inhibition appears to be indicative of a strong laterality effect, where generally the dominant hemisphere exerts inhibition on the nondominant one. These effects have been largely identified through functional studies in adult populations, but links between motor performance and callosal structure (especially during sensitive periods of neurodevelopment) remain largely unknown. We therefore investigated correlations between Purdue Pegboard performance (a test of motor function) and local callosal thickness in 170 right-handed children and adolescents (mean age: 11.5 ± 3.4 years; range, 6-17 years). Better task performance with the right (dominant) hand was associated with greater callosal thickness in isthmus and posterior midbody. Task performance using both hands yielded smaller and less significant correlations in the same regions, while task performance using the left (nondominant) hand showed no significant correlations with callosal thickness. There were no significant interactions with age and sex. These links between motor performance and callosal structure may constitute the neural correlate of interhemispheric inhibition, which is thought to be necessary for fast and complex unilateral motions and to be biased towards the dominant hand.
Source: Human Brain Mapping
DOI: 10.1002/hbm.22060
Institution: University of California, Los Angeles
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, U.S. National Library of Medicine, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G130320643, G1330507362, G143771443, PEDIATRIC STUDY CENTERS (PSCS) FOR A MRI STUDY OF NORMAL, G1757829149, Computational Anatomy and Multidimensional Modeling, G328544487, G347720180, HARDI Mapping of Disease Effects on the Brain, Novel PDEs for Cortical Mapping and Analysis in Disease, G363710439, G3642348494, UCLA Alzheimer's Disease Research Center, G3868918485, PEDIATRIC STUDY CENTERS (PSCS) FOR A MRI STUDY OF NORMAL, PEDIATRIC STUDY CENTERS (PSCS) FOR A MRI STUDY OF NORMAL, Pediatric Study Center (PSC) for a MRI Study of Normal Brain Development, G451214520, A Multidimensional Alzheimer's Disease Brain Atlas, G4660470923, General Clinical Research Center, Center for Computational Biology (CCB)(RMI), MRI STUDY OF NORMAL BRAIN DEVELOPMENT CLINICAL COORDINATING CENTER, A Multidimensional Alzheimer's Disease Brain Atlas, G5223152981, Computational Modeling of High-Field MR Images, PEDIATRIC STUDY CENTERS (PSCS) FOR A MRI STUDY OF NORMAL, PEDIATRIC STUDY CENTERS (PSCS)FOR A MRI STUDY OF NORMAL, G602052340, G6303498173, G6644087359, G679527571, DATA COORDINATING CENTER (DCC) FOR A MRI STUDY OF NORMAL, Laboratory of Neuro Imaging Resource (LONIR), G8243396638, G98731164
OpenAlex ID: W1898623574