Lipoprotein (a) and Other Dyslipidemia in Saudi Children with Nephrotic Syndrome (SSNS and SRNS)
Year: 2012
Type: article
Study design: Observational Study
Abstract: Hyperlip idemia is co mmonly associated with nephrotic syndrome (NS). We have investigated lipoprotein (a) (LP (a)) level and other lipid abnormalit ies in Saudi children with primary nephrotic syndrome (steroid sensitive and steroid resistant NS). Thirty eight children with primary nephrotic syndrome who were fo llo wed up at King Abdulaziz University in Jeddah were recruited for the study on second half of 2009. Their mean age ± SD =8.76± 3.8 years. They were classified into group 1; steroid sensitive nephrotic syndrome (SSNS), group 2; steroid resistant nephrotic syndrome in remission (SRNS®), group 3; SRNS not in remission , and compared them with 27 controls of normal ch ild ren. Seru m creat inine, seru m albumin and fasting serum lipids were measured in all patients. In addition urine protein was measured on the same day of b lood samples. There was a significant increase in cholesterol, triglyceride and low density lipoprotein (LDL) concentrations in SRNS as co mpared to controls, SSNS and SRNS®. All groups showed a significant increase in high density lipoprotein (HDL) levels . There was a significant increase in LP (a) level (P < 0.001) in SRNS group and in SSNS group (P< 0.05) compared to control group. However, a non significant increase (p =0.06) was observed in SRNS® group. No significant changes were observed in apoprotein A 1 (Apo AI) and Apo B levels between group 1, group 2, g roup 3 and the control group. In the SRNS group; there was positive correlation between cholesterol and triglyceride, cholesterol and LDL and trig lyceride and Apo B. There was negative correlat ion between cholesterol and albu min, triglyceride and albu min and LDL and albu min. In conclusion, SRNS in ch ild ren was associated with high LP (a) and dyslipidemia which was not completely normalized in children who achieved remission.
Source: JOURNAL OF HEALTH SCIENCE
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W189919393