A new reference preparation of human chorionic gonadotrophin and its subunits.
Year: 1976
Type: article
Abstract: The establishment of CR119 human chorionic gonadotropin (HCG), CR119 HCGalpha, and CR119 HCGbeta(3) as reference preparations for the immunoassay of HCG and its subunits by the WHO Expert Committee on Biological Standardization is reported. The interstitial cell stimulating activity of CR119 HCG is 13,450 IU/mg and has proportional in vivo stimulatory activities for thyroid stimulating and follicle stimulating activities. The potencies of these activities for subunit preparations are uniformly less than .02 in relation to the undissociated hormone, and are recoverable in amounts approximately 75% of the total upon recombination. Each preparation has chemical, physical, and antigenic properties which are consistent with those reported for equally pure preparations.
Source: Europe PMC (PubMed Central)
Authors: R E Canfield, G T Ross
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1900449871