Work

Why the Central Dogma: on the nature of the great biological exclusion principle

Year: 2015

Type: article

Abstract: The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from the digital information carriers, nucleic acids, to analog information carriers, proteins, which involves irreversible suppression of the digital information. Reviewers This article was reviewed by Itai Yanai, Martin Lercher and Frank Eisenhaber.

Source: Biology Direct

DOI: 10.1186/s13062-015-0084-3

Author: Eugene V. Koonin

Institutions: National Institutes of Health, National Center for Biotechnology Information

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,890

Funders: U.S. Department of Health and Human Services, National Institutes of Health, U.S. National Library of Medicine