Work

Small Molecule Inhibitors of Anthrax Toxin–induced Cytotoxicity Targeted Against Protective Antigen

Year: 2011

Type: article

Abstract: Two molecular scaffolds were designed using the CAVEAT molecular design package to inhibit the oligomerization of protective antigen (PA(63) ), a key protein component of anthrax toxin. The inhibitors were designed to prevent heptamerization of PA(63) by mimicking key residues of PA(63) needed for the intermolecular interactions that stabilize the heptamer. Using the scaffolds identified by CAVEAT, seven candidate inhibitors were synthesized and tested for their ability to inhibit anthrax toxin-induced cytotoxicity, with three of the agents demonstrating modest inhibition in murine J774A.1 macrophage cells.

Source: Chemical Biology & Drug Design

DOI: 10.1111/j.1747-0285.2011.01285.x

Authors: Charles Rubert Pérez, Daneli López‐Pérez, Jean Chmielewski, Mark Lipton

Institution: Purdue University West Lafayette

Language: English

Topic: Bacillus and Francisella bacterial research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1902801355

FWCI: 0.632

Cites: 39

Cited by: 10

Related to: 10