Work

Molecular characterization of mutations affecting expression level and growth rate-dependent regulation of the Escherichia coli zwf gene

Year: 1992

Type: article

Abstract: We characterized three cis dominant mutations which elevate glucose 6-phosphate dehydrogenase level. Growth rate-dependent regulation and oxidative stress control of enzyme level were altered by the mutations. DNA sequencing and transcript mapping showed that the "up" mutations created new promoters whose hyperactive expression overrides the normal regulation of the native promoter.

Source: Journal of Bacteriology

DOI: 10.1128/jb.174.2.623-626.1992

Authors: D L Rowley, W P Fawcett, R E Wolf

Institution: University of Maryland, Baltimore County

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G187195762, DNA Binding and Transcriptional Activation by SoxS