Work

Biomarker Use in Colorectal Cancer Therapy

Year: 2011

Type: article

Abstract: Biomarkers reflective of the molecular and genetic heterogeneity in colorectal cancers now guide certain aspects of clinical management and offer great potential for enrichment, stratification, and identification of novel therapeutic targets in drug development. Using case-based examples, this article reviews biomarkers that have an established role in the clinical management of colorectal cancer: mismatch repair protein testing and KRAS and BRAF mutational analysis. A selection of biomarkers undergoing validation for future clinical application is presented, and the dynamic and challenging interface between biomarkers in research and clinical practice is discussed.

Source: Journal of the National Comprehensive Cancer Network

DOI: 10.6004/jnccn.2011.0105

Authors: Robin K. Kelley, Grace Wang, Alan P. Venook

Institutions: University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Genomic Health, National Comprehensive Cancer Network, University of California, San Francisco, National Cancer Institute