The Role of DNA Methylation in Type 1 and 2 Diabetes as Related to Endothelial Cell Dysfunction
Year: 2015
Type: article
Abstract: A major clinical problem associated with type 1 and 2 diabetes is the debilitating long term complications seen in this disease.This review will discuss 1) the role of epigenetics in type 1 and 2 diabetes, and 2) the dysfunction of endothelial cells in this disease, especially as related to blood vessel growth.While many tissues are affected in DM, pathologies associated with the endothelial cell are often central to these tissue problems.With the identification of epigenetic changes, (e.g.DNA methylation, histone modification, etc.) as processes associated with both DM and MM, investigators now have another potential target for investigation of the molecular mechanisms that may explain the persistent dysfunction seen in the many tissues affected in this disease.
Source: MOJ Anatomy & Physiology
Author: Michael P Sarras
Institution: Rosalind Franklin University of Medicine and Science
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1905520256