The studies on cystatin B deficient mice: neurochemical and behavioural alterations in animal model of progressive myoclonus epilepsy of Unverricht–Lundborg type
Year: 2007
Type: dissertation
Abstract: The study aimed to further characterize the neurochemical and behavioural phenotype of cystatin B deficient mice, which are the animal model of progressive myoclonus epilepsy of Unverricht–Lundborg type. Cystatin B deficiency provokes impairment in glutamatergic neuronal circuits and enhances tryptophan metabolism along kynurenine and serotonin pathways in the brain of mutant mice. Observed neurochemical alterations may contribute to the pathological mechanisms and might have a causal impact to the formation of neurological phenotype seen in diseased humans. Käesolevas uurimuses kirjeldatakse täpsemalt Unverricht-Lundborgi tüüpi müokloonilise epilepsia mudellooma tsüstatiin B geeni puudulikkusega hiire neurokeemilist ja käitumuslikku fenotüüpi. Leitud muutused mutantsete hiirte aju trüptofaani metabolismis ning erutus– ja pidurdusnärviringete omavahelises tasakaalus võivad mõjutada müokloonilisele epilepsiale iseloomuliku haiguspildi väljakujunemist ning selgitada patoloogilisi mehhanisme inimesel.
Author: Annika Vaarmann
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1906921630