Work

VorinostatSAHA Promotes Hyper-Radiosensitivity in Wild Type p53 Human Glioblastoma Cells.

Year: 2014

Type: article

Abstract: in the p53 mutant U118 cells to levels similar to the p53 wild type cells. TMZ also promoted HRS at doses as low as 0.15 Gy. These finding indicate that HRS can be promoted in p53 wild type glioblastoma cells through a functional PTEN to delay DNA repair and sensitize cells to low dose radiation. Promotion of HRS thus appears to be a viable approach for GBM that could be used as a basis to develop new Phase I/II studies.

Source: PubMed

Authors: Eric Diss, NarasimhaRao Nalabothula, Duc Nguyen, Elizabeth Chang, Young Kwok, France Carrier

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Award: Biomodulation of anticancer drugs targeting DNA

OpenAlex ID: W190758130

FWCI: 0.998

Cites: 33

Cited by: 23

Related to: 10