Work

Reduced microglial CX3CR1 expression delays neurofibromatosis‐1 glioma formation

Year: 2012

Type: article

Abstract: Although traditional models of carcinogenesis have largely focused on neoplastic cells, converging data have revealed the importance of non-neoplastic stromal cells in influencing tumor growth and progression. Leveraging a genetically engineered mouse model of neurofibromatosis type 1 (NF1)-associated optic glioma, we now demonstrate that stromal microglia express the CX3CR1 chemokine receptor, such that reduced CX3CR1 expression decreases optic nerve microglia. Moreover, genetic reduction of Cx3cr1 expression in Nf1 optic glioma mice delays optic glioma formation. Coupled with previous findings demonstrating that microglia maintain optic glioma growth, these new findings provide a strong preclinical rationale for the development of future stroma-directed glioma therapies in children.

Source: Annals of Neurology

DOI: 10.1002/ana.23813

Authors: Winnie W. Pong, Samantha B. Higer, Scott M. Gianino, Ryan J. Emnett, David H. Gutmann

Institution: Washington University in St. Louis

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Eye Institute, National Cancer Institute, National Institute of Neurological Disorders and Stroke