Evaluation of technological and functional properties of a new probiotic Lactobacillus fermentum ME-3
Year: 2005
Type: dissertation
Abstract: Backround: In persons without clinical symptom it is difficult to assess an impact of probiotics regarding its effect on health. We evaluated the functional efficacy of the probiotic Lactobacillus fermentum ME-3 in healthy volunteers by measuring the influence of two different formulations on intestinal lactoflora, fecal recovery of the probiotic strain and oxidative stress markers of blood and urine after 3 weeks consumption. Methods: Two studies with healthy adults were performed; altogether 45 randomly allocated persons consumed either the ME-3 capsules/placebo or fermented goat milk/goat milk in a daily of dose 9.2 to 11.8 log CFU respec- tively for 3 weeks. The fecal lactoflora composition, fecal ME-3 recovery, effect of the consumption on intestinal lactoflora, and oxidative stress markers of blood (total antioxidative activity; total antioxidative status and glutathione red-ox ratio) and urine (8-isoprostanes) was measured. Results: ME-3 was well tolerated and a significant increase in total fecal lactobacilli yet no predominance of ME-3 was detected in all study groups. Fecal recovery was documented by molecular methods only in fermented milk group, however the significant improvement of blood TAA and TAS indices
Author: Epp Songisepp
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: green
Funders: Eesti Teadusfondi, Tartu Ülikool
OpenAlex ID: W1910460605