Work

In vivo measurement of CBF using 17O NMR signal of metabolically produced H217O as a perfusion tracer

Year: 2012

Type: article

Abstract: The cerebral metabolic rate of oxygen of small animals can be reliably imaged using the in vivo (17) O magnetic resonance approach at high field. However, a separate measurement is required for imaging the cerebral blood flow in the same animal. In this study, we demonstrate that the (17) O NMR signal of metabolically produced H2 (17) O in the rat brain following an (17) O2 inhalation can serve as a perfusion tracer and its decay rate can be used to determine the absolute values of cerebral blood flow across a wide range of animal conditions. This finding suggests that the in vivo (17) O magnetic resonance approach is capable of imaging both cerebral metabolic rate of oxygen and cerebral blood flow simultaneously and noninvasively; and it provides new utilities for studying the cerebral oxygen metabolism and perfusion commonly associated with brain function and diseases.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.24469

Authors: Xiao‐Hong Zhu, Yi Zhang, Hannes M. Wiesner, Kamil Ugurbil, Wei Chen

Institutions: University of Minnesota, Max Planck Institute for Biological Cybernetics

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: W. M. Keck Foundation, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources