Formation of osteoclasts from blood monocytes during 1 alpha-OH Vit D-stimulated bone resorption in mice.
Year: 1981
Type: article
Abstract: In order to investigate a monocyte origin for osteoclasts, tritiated thymidine labelled blood monocytes, harvested from the blood of donor mice, were injected intravenously into syngeneic recipient animals in which osteoclast formation was being stimulated by concomitant intraperitoneal injections of 1 alpha-hydroxycholecalciferol. Labelled osteoclasts were found in autoradiographs prepared from the femurs of recipient mice, demonstrating for the first time that, during hormonally stimulated osteoclast formation, blood monocytes form one source of osteoclasts.
Source: Europe PMC (PubMed Central)
Authors: S M Tinkler, J E Linder, D M Williams, N W Johnson
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W19109719