Genome‐wide scans of genetic variants for psychophysiological endophenotypes: A methodological overview
Year: 2014
Type: review
Abstract: This article provides an introductory overview of the investigative strategy employed to evaluate the genetic basis of 17 endophenotypes examined as part of a 20-year data collection effort from the Minnesota Center for Twin and Family Research. Included are characterization of the study samples, descriptive statistics for key properties of the psychophysiological measures, and rationale behind the steps taken in the molecular genetic study design. The statistical approach included (a) biometric analysis of twin and family data, (b) heritability analysis using 527,829 single nucleotide polymorphisms (SNPs), (c) genome-wide association analysis of these SNPs and 17,601 autosomal genes, (d) follow-up analyses of candidate SNPs and genes hypothesized to have an association with each endophenotype, (e) rare variant analysis of nonsynonymous SNPs in the exome, and (f) whole genome sequencing association analysis using 27 million genetic variants. These methods were used in the accompanying empirical articles comprising this special issue, Genome-Wide Scans of Genetic Variants for Psychophysiological Endophenotypes.
Source: Psychophysiology
DOI: 10.1111/psyp.12343
Institutions: University of Minnesota, University of Michigan
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: G1050708039, G1052645489, G1104670545, G1342740831, Twin Study of Female Alcoholism and Other Disorders, G1505664221, Substance Abuse & Behavioral Disinhibition: Integrating Genes & Environment, G1766463397, G2399428660, Studies of Rare Genetic Variation in the Isolated Population of Sardinia, Adolescent drinking and midlife outcomes: A prospective cotwin control study, G3089696063, G3806324649, G3867764004, G3935526752, G5072599845, Twin Study of ADHD, CD and Substance Abuse, G5322692167, G5621506578, Computational and statistical models for human genetics, Substance Abuse & Behavioral Disinhibition: Integrating Genes & Environment, Twin Family Study of Vulnerability to Substance Abuse, Adult consequences of youth substance use: Twin study enriched for SUD risk, Twin Family Study of Vulnerability to Substance Abuse, Studies of Rare Genetic Variation in the Isolated Population of Sardinia, G8368690559, G8400609563, Delineating Gene, Environment, & Development Interplay in Substance Use Disorders, G937110402
OpenAlex ID: W1911744801