Year: 2015
Type: article
Abstract: Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as 'scavenging', or 'decoy', chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as 'atypical chemokine receptors', or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.
Source: British Journal of Pharmacology
DOI: 10.1111/bph.13182
Institutions: Université Paris-Sud, Inserm, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, University of Glasgow, Humanitas University, University of Milan, National Institutes of Health, National Institute of Allergy and Infectious Diseases, University of Birmingham, Medical Research Council, University of Brescia, Institute for Research in Biomedicine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: National Science Foundation, Wellcome Trust, E-Rare, European Commission, Institut National de la Santé et de la Recherche Médicale, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Ministero della Salute, Ministero dell’Istruzione, dell’Università e della Ricerca, Associazione Italiana per la Ricerca sul Cancro, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Helmut Horten Stiftung, National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases, NHLBI Division of Intramural Research
OpenAlex ID: W1911903347