Year: 1953
Type: article
Abstract: The metabolic characteristics of a new Mendelian recessive syndrome in mice have been described in previous publications. The condition is characterized by an adult body weight of 50-100 g. instead of a normal 20-30 g., sterility,'0 hyperglycemia and glycosuria,'7 atrophic changes and ulceration of the skin, and decreased life span. Histopathological studies reveal enlarged islets of Langerhans; no definite histological evidence of other types of endocrine disturbances has been noted.8 Total basal oxygen consumption is not greater than that of the non-obese animals in spite of a much greater body weight.'9 Spontaneous running activity is low.'8 Although obese animals show sensitivity to thyroxine as indicated by respiratory rate, weight loss, and toxicity, studies on radio-iodine uptake and of resistance to anoxia yield no evidence of impairment of thyroid function.7 Administration of thiouracil to non-obese animals fails to reproduce any aspect of the syndrome.2 ' The caloric intake of the obese mice is about 25 per cent greater than that of the non-obese. If allowed to select their nutrients freely,
Source: PubMed Central
Authors: J MAYER, R J BARRNETT
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1916388312