Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study
Year: 2015
Type: article
Study design: Observational Study
Abstract: Incidence rates of differentiated thyroid carcinoma (TC) have increased in many countries. Adiposity and dietary risk factors may play a role, but little is known on the influence of energy intake and macronutrient composition. The aim of this study was to investigate the associations between TC and the intake of energy, macronutrients, glycemic index (GI) and glycemic load in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,274 middle-age participants (70.2% women) from ten European countries. Dietary data were collected using country-specific validated dietary questionnaires. Total carbohydrates, proteins, fats, saturated, monounsaturated and polyunsaturated fats (PUFA), starch, sugar, and fiber were computed as g/1,000 kcal. Multivariable Cox regression was used to calculate multivariable adjusted hazard ratios (HR) and 95% confidence interval (CI) by intake quartile (Q). After a mean follow-up time of 11 years, differentiated TC was diagnosed in 556 participants (90% women). Overall, we found significant associations only with total energy (HRQ4 vs .Q1 , 1.29; 95% CI, 1.00-1.68) and PUFA intakes (HRQ4 vs .Q1 , 0.74; 95% CI, 0.57-0.95). However, the associations with starch and sugar intake and GI were significantly heterogeneous across body mass index (BMI) groups, i.e., positive associations with starch and GI were found in participants with a BMI ≥ 25 and with sugar intake in those with BMI < 25. Moreover, inverse associations with starch and GI were observed in subjects with BMI < 25. In conclusion, our results suggest that high total energy and low PUFA intakes may increase the risk of differentiated TC. Positive associations with starch intake and GI in participants with BMI ≥ 25 suggest that those persons may have a greater insulin response to high starch intake and GI than lean people.
Source: International Journal of Cancer
DOI: 10.1002/ijc.29693
Authors: Raul Zamora-Ros, Sabina Rinaldi, Konstantinos K. Tsilidis, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Françoise Clavel-Chapelon, Sylvie Mesrine, Verena A. Katzke, Tilman Kühn, Jana Förster, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleni Klinaki, Giovanna Masala, Sabina Sieri, Fulvio Ricceri, Rosario Tumino, Amalia Mattiello, Petra H.M. Peeters, H. Bas Bueno-de-Mesquita, Dagrun Engeset, Guri Skeie, Marcial Argüelles, Antonio Agudo, María-José Sánchez, María-Dolores Chirlaque, Aurelio Barricarte, Saioa Chamosa, Martin Almquist, Ada Tosovic, Joakim Hennings, Maria Sandström, Julie A Schmidt, Kay-Thee Khaw, Nicholas J. Wareham, Amanda J. Cross, Nadia Slimani, Graham Byrnes, Isabelle Romieu, Elio Riboli, Silvia Franceschi
Institutions: Centre international de recherche sur le cancer, University of Ioannina, Imperial College London, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Danish Cancer Society, German Cancer Research Center, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Academy of Athens, Hellenic Health Foundation, Harvard University, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, Azienda Usl 8 Arezzo, Federico II University Hospital, University of Naples Federico II, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Gobierno del Principado de Asturias, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Instituto de Salud Pública de Navarra, Biogipuzkoa Health Research Institute, Skåne University Hospital, Umeå University, University of Oxford, University of Cambridge, MRC Epidemiology Unit
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Compagnia di San Paolo, Deutsches Krebsforschungszentrum, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Ligue Contre le Cancer, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut National Du Cancer, Institut Gustave-Roussy, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, National Cancer Institute
OpenAlex ID: W1917836448