Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium
Year: 2015
Type: article
Abstract: The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future.
DOI: 10.3402/jev.v4.27575
Authors: Peter J. Quesenberry, Jason Aliotta, Giovanni Camussi, Asim B. Abdel‐Mageed, Sicheng Wen, Laura Goldberg, Huang‐Ge Zhang, Ciro Tetta, Jeffrey Franklin, Robert J. Coffey, Kirsty Danielson, Vinita Subramanya, Ionita Ghiran, Saumya Das, Clark C. Chen, Kae M. Pusic, Aya D. Pusic, Devasis Chatterjee, Richard P. Kraig, Leonora Balaj, Mark Dooner
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,410
Funders: Vanderbilt University, Tulane University, University of Louisville, National Institutes of Health, National Heart, Lung, and Blood Institute, NIH Office of the Director, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Office of Strategic Coordination, National Center for Advancing Translational Sciences, Common Fund
Awards: Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI, Novel Role for Circulating extracellular RNAs in Human Heart Failure, Targeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screeni, Targeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screeni, Regulation of renal and bone marrow injury by extracellular vesicle non-coding RN, exRNA released by glioblastoma alters brain microenvironment, G3489812386, G4388586864, G4648848808, Secreted RNA during CRC progression biogenesis function and clinical markers, SPORE in GI Cancer, Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI, G5249137464, Regulation of renal and bone marrow injury by extracellular vesicle non-coding RN, Hematology Post Doctoral Training, Exosome RNA-Therapeutics to Promote CNS Myelination, Fruit exosome-like particles for therapeutic delivery of extracellular miRNAs, Role of EGFR ligand-containing exosomes in colorectal cancer, G9000085992, Molecular and Cellular Basis for Digestive Diseases
OpenAlex ID: W1918903475