Work

Bordetella pertussis waaAEncodes a Monofunctional 2-Keto-3-Deoxy- d -manno-Octulosonic Acid Transferase That Can Complement anEscherichia coli waaAMutation

Year: 1999

Type: article

Abstract: Bordetella pertussis lipopolysaccharide (LPS) contains a single 2-keto-3-deoxy-D-manno-octulosonic acid (Kdo) residue, whereas LPS from Escherichia coli contains at least two. Here we report that B. pertussis waaA encodes an enzyme capable of transferring only a single Kdo during the biosynthesis of LPS and that this activity is sufficient to complement an E. coli waaA mutation.

Source: Journal of Bacteriology

DOI: 10.1128/jb.181.8.2648-2651.1999

Authors: Tomoko Isobe, Kimberley A. White, Andrew G. Allen, Michael Peacock, Christian R. H. Raetz, Duncan J. Maskell

Institutions: University of Cambridge, Duke University, Duke Medical Center

Language: English

Topic: Bacterial Infections and Vaccines

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G2215253020, Biosynthesis And Function Of Lipopolysaccharides