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Growth of Cryptococcus neoformans Within Human Macrophages In Vitro

Year: 1973

Type: article

Abstract: Macrophages cultured from human peripheral blood monocytes were infected with Cryptococcus neoformans in vitro. Although C. neoformans were actively ingested, there was no detectable intracellular killing by macrophages. Over 2 days or more, intracellular fungi grew more rapidly than a corresponding inoculum of extracellular cryptococci growing in tissue culture medium containing human serum. Macrophages were induced to develop into cells which appeared to be activated by morphological and phagocytic criteria. However, these activated cells did not acquire an ability to kill or inhibit intracellular growth of C. neoformans. There were no detectable differences between macrophages from normal subjects and those from cryptococcosis patients.

Source: Infection and Immunity

DOI: 10.1128/iai.7.2.231-236.1973

Authors: Richard D. Diamond, John E. Bennett

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1922449073

FWCI: 6.294

Cites: 17

Cited by: 150

Related to: 10