Work

Differential Utilization of Calcitonin Gene Regulatory DNA Sequences in Cultured Lines of Medullary Thyroid Carcinoma and Small-Cell Lung Carcinoma

Year: 1990

Type: article

Abstract: Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.10.4.1773

Authors: A de Bustros, R Y Lee, D Compton, T Y Tsong, S B Baylin, B D Nelkin

Institution: Johns Hopkins University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Johns Hopkins University, National Cancer Institute