A Study of Antifungal and Antiaflatoxigenic Action of Newly Synthesized Analogues of Dehydroacetic Acid
Year: 2010
Type: article
Abstract: Mycelial growth and afl atoxin B 1 accumulation by toxigenous mould Aspergillus fl avus were inhibited by dehydroacetic acid and its newly synthesized analogues, 4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (DHT) and 5-Bromo-4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2Hpyrane-2-one (BrDHT) during the growth of investigated mould on solid substrate (soy-beans).Experiments were carried out in a stationary culture at 20 0 C and 30 0 C, respectively, during 21 days.Mycelial growth (biomass dry weight) was determined by measuring the chitin content and concentration of afl atoxin B 1 (AFB 1 ) was quantitated by HPLC.Concentrations of DHA and DHT of 0.1 and 0.2 μg x g -1 of substrate were stimulated, but concentrations higher than 0.5 μg x g -1 of these compounds, mould growth and AFB 1 accumulation partially inhibited.In experiments with 0.2 μg x g -1 of BrDHT mould growth and AFB 1 accumulation were inhibited completely depending on the time and temperature of cultivation.
Institution: University of Zagreb
Language: Croatian
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1925908417