Work

Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus

Year: 2014

Type: review

Abstract: High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.

Source: IUBMB Life

DOI: 10.1002/iub.1289

Authors: Jennifer Fishovitz, Juan A. Hermoso, Mayland Chang, Shahriar Mobashery

Institutions: University of Notre Dame, Consejo Superior de Investigaciones Científicas, Instituto de Química Física Blas Cabrera

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases