Work

Vector-based siRNA delivery strategies for high-throughput screening of novel target genes.

Year: 2005

Type: article

Abstract: Application of siRNA in high-throughput fashion is still in its early phase although the principle has been established for three years. In this review, we outline the different vector-based siRNA delivery platforms as well as resources that are becoming available for high-throughput applications, and some initial outcomes of vector siRNA high-throughput screening efforts using vector encoded siRNA. It is expected that further improvement of the siRNA technology and availability of the siRNA resources will help to materialize the potential of siRNA for functional genomics and drug target validation.

Source: PubMed

Authors: Meihong Chen, Quan Du, Hong-Yan Zhang, Claes Wahlestedt, Zicai Liang

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences, Karolinska Institutet

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W192889104

FWCI:

Cites: 31

Cited by: 14

Related to: 20