The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
Year: 2013
Type: article
Abstract: Although we did not observe any behavioral motor improvement with Colivelin and dPEG-Colivelin, we did, in fact, find significant up-regulation of p-Akt in the ST of 40 mg/20g Colivelin treated R6/2 mice as compared to saline treated R6/2 mice.However, we did not observe any significant difference in the level of p-Akt in the PFC with Colivelin and dPEG-Colivelin treatments as compared to saline treated groups.Moreover, significant increase in p-JNK was observed in the ST and PFC of 40 mg/20g Colivelin treated R6/2 mice.Alternatively, we did not observe any behavioral improvements with Ceftriaxone or Sulforaphane.v Acknowledgments To start with, I would like to thank my mentor and advisor Dr. Youssef Sari.Working with him over the past two years has been a growing experience of monumental proportions and I am thankful to have been working with a person who was willing to go out on a limb and believe in my potential.
Author: Jessica Ciesler
Institution: University of Toledo
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1928928744