Work

Giardicidal activity of lactoferrin and N-terminal peptides

Year: 1995

Type: article

Abstract: Human and bovine lactoferrins and their derived N-terminal peptides were giardicidal in vitro. Fe3+, but not Fe2+, protected trophozoites from both native lactoferrin and peptides, although the latter lack iron-binding sites. Other divalent metal ions protected only against native lactoferrin. Log-phase cells were more resistant to killing than stationary-phase cells. These studies suggest that lactoferrin, especially in the form of the N-terminal peptides, may be an important nonimmune component of host mucosal defenses against Giardia lamblia.

Source: Infection and Immunity

DOI: 10.1128/iai.63.11.4550-4552.1995

Authors: J M Turchany, S B Aley, F D Gillin

Institution: University of California San Diego

Language: English

Topic: Parasitic Infections and Diagnostics

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development