Work

Angiogenesis and intramembranous osteogenesis

Year: 2013

Type: review

Abstract: BACKGROUND: Angiogenesis is likely critical for the process of intramembranous osteogenesis; however, the developmental relationship between blood vessels and bone mineralization is not well studied within intramembranous bones. Given its importance, changes in angiogenesis regulation are likely to contribute to evolutionarily and medically relevant craniofacial variation. RESULTS: We summarize what is known about the association between angiogenesis and intramembranous osteogenesis, supplementing with information from the better-studied processes of endochondral ossification and distraction osteogenesis. Based on this review, we introduce a model of angiogenesis during early intramembranous osteogenesis as well as a series of null hypotheses to be tested. CONCLUSIONS: This model can serve as a basis of future research on the spatio-temporal association and regulatory interactions of mesenchymal, vascular, and bone cells, which will be required to illuminate the potential effects of angiogenesis dysregulation on craniofacial skeletal phenotypes.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.23992

Authors: Christopher J. Percival, Joan T. Richtsmeier

Institution: Pennsylvania State University

Language: English

Topic: Craniofacial Disorders and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Texas at Austin, National Institute of Dental and Craniofacial Research