Derivatization of Artesunate and Dihydroartemisinin for Colorimetric Analysis using p-dimethylaminobenzaldehyde
Year: 2011
Type: article
Abstract: We set out to develop an alternative simple, accurate and precise method for the determination ofartesunate and dihydroartemisinin in bulk samples and dosage forms. The method involves thereaction of the reactive methylene centres generated in situ from the acid decomposition of theartemisinin derivatives with p-dimethylaminobenzaldehyde (DMAB). DMAB was reduced to thepurple-coloured alcohol and this was quantitatively used to estimate the concentrations of theartemisinin derivatives. The new procedure was carried out at 60oC in less than 30 minutes withexcellent calibration data. The method was accurate and precise and was found equivalent to theInternational Pharmacopoeia’s method for the assay of these drugs. The method could find applicationas an alternative in-process and after manufacture method for the quality control of artesunate anddihydroartemisinin.
Authors: Olajire A. Adegoke, Afolake O. Osoye
Institution: University of Ibadan
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W1932290397