Work

ER-associated degradation: Protein quality control and beyond

Year: 2014

Type: review

Abstract: Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up misfolded. Cells evolved protein quality control systems to ensure that these potentially toxic species are detected and eliminated. The best characterized of these pathways, the ER-associated protein degradation (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the endoplasmic reticulum (ER). There is also increasing evidence that ERAD controls other ER-related functions through regulated degradation of certain folded ER proteins, further highlighting the role of ERAD in cellular homeostasis.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201312042

Authors: Annamaria Ruggiano, Ombretta Foresti, Pedro Carvalho

Institutions: Universitat Pompeu Fabra, Centre for Genomic Regulation

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Howard Hughes Medical Institute